TAOK inhibitor 43

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TAOK抑制剂43是一种新型有效、选择性、ATP竞争性TAO激酶(TAOK)抑制剂，针对TAOK1和TAOK2的IC50分别为11和15 nM。

TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively; increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growth in centrosome-amplified SKBR3 or BT549 breast cancer cell models.

TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells.

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CP 43 | CP43 | CP-43

MAPK/ERK Signaling

MEK

MEK

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850467-66-2

384.5

C25H24N2O2

>98% (HPLC)

In Vitro:?DMSO : 62.5 mg/mL (162.56 mM)

O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NCC(NC3CCCC4=C3C=CC=C4)=O

N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide

(-20℃)

With Ice Pack

≥ 2 years